IS CREATINE DANGEROUS? HERE’S WHAT THE RESEARCH SAYS12 July 2018
Over the last 10-plus years, there probably has not been a supplement more popular or one researched more often than creatine monohydrate. Creatine has found its place among bodybuilders, fitness enthusiasts, and athletes looking for improvements in strength, muscle hypertrophy, and athletic performance. This article will provide a brief review of the literature describing the role of creatine during activity and the health effects of creatine supplementation for apparently healthy individuals cleared by a physician. Additionally, this article will address which physical activities might benefit from creatine supplementation and which activities might have a negligible effect, or possibly worsen, with creatine supplementation.
It is important to start with an understanding of creatine’s role in the production of energy. At the cellular level, macronutrients (carbohydrates, fats, protein) are converted into adenosine triphosphate (ATP). ATP is the body’s energy source (a high energy phosphate compound) used to fuel bodily functions and physical activity (1, 2). However, muscle cells store ATP in limited quantities. Since the supply of ATP in each cell is limited, cells must have a means of producing more. There are three main bioenergetic pathways that produce ATP. These include the ATP-PC, glycolytic, and oxidative pathway systems (1, 2). For the sake of this discussion we will focus on the ATP-PC system.
ATP and phosphocreatine (PC) are sometimes referred to as phosphagens, and, therefore, the ATP-PC system is sometimes referred to as the phosphagen system (1, 2). The ATP-PC system primarily provides energy for high intensity, short duration bouts of activity (anaerobic) such as 50 meter sprints and Olympic weightlifting (1). However, the ATP-PC system is activated at the onset of any activity, regardless of intensity, due to its ability to rapidly produce energy in comparison to the glycolytic and oxidative pathways (1).
The ATP-PC system produces ATP faster than any other bioenergetic pathway. Phosphocreatine supplies the phosphate that combines with adenosine diphosphate (ADP) to form ATP (1). Conversely, the breakdown of ATP releases the energy necessary for muscle contraction. The ATP-PC system is very good at supplying energy rapidly, however, it cannot supply energy for prolonged periods of time (10 seconds or less) and thus other systems (glycolytic & oxidative) must now produce ATP (1). And as said before, the glycolytic and oxidative pathways are slower at producing ATP than the ATP-PC system.
Are There Health Risks Associated with Creatine Supplementation?
Research has not proven long term effects associated with creatine supplementation, and it is believed that an eight-week creatine supplementation regimen is safe (1). There have been anecdotal reports that creatine supplementation may cause dehydration, muscle cramps, and heat exhaustion; however, none of these reports have been backed by scientific and sports medicine communities (3, 4). In fact, the most common side effect from creatine supplementation is weight gain caused by water retention (1).
What Type of Activities Benefit from Creatine Supplementation?
The body is dependent upon muscle stores of phosphocreatine during activities involving short bursts of high intensity activity. Theoretically, creatine supplementation can improve anaerobic performance by increasing muscle stores of phosphocreatine thus allowing greater amounts of ATP to be regenerated. This will in effect help prevent a decrease in power output. Another proposed benefit of creatine supplementation is the associated increase in strength and muscle mass when combined with heavy resistance training (5). An increase in strength and muscle mass is beneficial for anaerobic sports such as football, shot put, and powerlifting.
What Type of Activities Might Be Hampered by Creatine Supplementation?
More research is needed to determine which activities are not improved by creatine supplementation. Recent studies have shown that creatine supplementation does not improve performance for resistance trained women, swimmers and soccer players performing intervals. A study by Ferguson and Syrotuik shows that creatine supplementation combined with 10 weeks of resistance training may not improve strength or lean body mass (greater than resistance training only) for previously experienced trained women (6). In another study by Dawson, Vladich, and Blanksby, four weeks of creatine supplementation did not significantly improve sprint performance for competitive junior swimmers (7). In a study by Biwer et al., creatine supplementation did not show improvement in performance when submaximal running was interspersed with high-intensity intervals (8). Additionally, there is some speculation that creatine supplementation aids in muscle recovery following exercise. While some studies show that creatine may improve muscle damage recovery following running, creatine supplementation does not seem to reduce muscle damage or improve an athlete’s ability to recover following high force eccentric and hypoxic resistance exercise (9, 10).
Even though there are numerous studies looking at the effects of creatine supplementation, much more still needs to be done. At this time, creatine does appear to be safe if consumed in proper recommended doses and is effective for anaerobic events. However, the efficacy of creatine for various aerobic activities has yet to be determined.
- Powers S, Howley E. Bioenergetics. Exercise Physiology Theory and Application to Fitness and Performance. 6th ed. New York: McGraw-Hill; 2007.
- Conley M. Bioenergetics of Exercise and Training. In: Baeschle T, ed. Essentials of Strength Training and Conditioning. 2nd ed. Champaign: Human Kinetics; 2000:75-88.
- Volek JS, Mazzetti SA, Farquhar WB, et al. Physiological responses to short-term exercise in the heat after creatine loading. Med Sci Sports Exerc. Jul 2001;33(7):1101-1108.
- Terjung RL, Clarkson P, Eichner ER, et al. American College of Sports Medicine roundtable. The physiological and health effects of oral creatine supplementation. Med Sci Sports Exerc. Mar 2000;32(3):706-717.
- Rawson ES, Volek JS. Effects of creatine supplementation and resistance training on muscle strength and weightlifting performance. J Strength Cond Res. Nov 2003;17(4):822-831.
- Ferguson TB, Syrotuik DG. Effects of creatine monohydrate supplementation on body composition and strength indices in experienced resistance trained women. J Strength Cond Res. Nov 2006;20(4):939-946.
- Dawson B, Vladich T, Blanksby BA. Effects of 4 weeks of creatine supplementation in junior swimmers on freestyle sprint and swim bench performance. J Strength Cond Res. Nov 2002;16(4):485-490.
- Biwer CJ, Jensen RL, Schmidt WD, et al. The effect of creatine on treadmill running with high-intensity intervals. J Strength Cond Res. Aug 2003;17(3):439-445.
- Rawson ES, Conti MP, Miles MP. Creatine supplementation does not reduce muscle damage or enhance recovery from resistance exercise. J Strength Cond Res. Nov 2007;21(4):1208-1213.
- Rawson ES, Gunn B, Clarkson PM. The effects of creatine supplementation on exercise-induced muscle damage. J Strength Cond Res. May 2001;15(2):178-184.